endTB PK-1-2


Meet the Leadership Team Join the team

News & Blog

Latest updates from ird

Innovative Worldwide Clinical Trial for Multidrug-Resistant Tuberculosis Completes Enrollment

18th October 2021

Boston/Paris/Karachi, October 18, 2021 — 750 patient volunteers from four continents have enrolled in a trial that aims to find safer, shorter, and effective treatments for multidrug-resistant tuberculosis (MDR-TB), an airborne, infectious disease that has grown resistant to standard medications. A group of scientists and clinicians led by Médecins Sans Frontières (MSF), Partners In Health (PIH) and Interactive Research and Development (IRD) make up the endTB consortium conducting the groundbreaking study funded by Unitaid.

Started in 2017, this phase III randomized controlled trial recruited 750 patients with MDR-TB across seven countries: Georgia, India, Kazakhstan, Lesotho, Pakistan, Peru, and South Africa. It compares five new treatment regimens for treating MDR-TB containing two of the three new TB drugs developed in recent years, bedaquiline and delamanid, in combination with other existing oral TB drugs. This new generation of drugs, which were developed after a nearly 50 year drought in new anti-TB drug classes, now allows for the development of radically shorter (6 or 9 months versus as long as two years), more tolerable, injection-free treatments for MDR-TB.

“An old enemy of mankind, tuberculosis remains the deadliest infectious disease today. And MDR-TB is the most cruel and merciless version. The coming results of this trial could be lifechanging for more than 500,000 people suffering from MDR-TB, and may help to appropriately treat millions of patients—tomorrow and in decades to come”, says Dr Lorenzo Guglielmetti, endTB Project Leader for MSF and co-principal investigator of the trial.

“The results, which will be available in 2023, will be relevant to a wide range of patients living with MDR-TB. This is because of the diversity in the study population: while all were sick with TB resistant to standard treatment, the study population included people from a range of racial and ethnic backgrounds and people affected by comorbidities that occur commonly with MDR-TB like HIV, Hepatitis C or diabetes. People with these conditions are often excluded from TB trials making it difficult for doctors to know how best to treat their patients.”, adds Dr Carole Mitnick, Professor of Global Health and Social Medicine at Harvard Medical School, and co-principal investigator of the trial.

“This is a significant milestone in Unitaid’s largest investment into TB. With sobering new data from the Global TB Report showing progress against TB slipping backwards for the first time in over a decade, new tools and treatments are more crucial than ever. The innovative multi-country endTB trial will benefit not only people with MDR-TB – a more complex and difficult to cure strain of TB – but it is also building long-term capacity in the countries that are managing this multi-faceted clinical trial,” said Dr Philippe Duneton, Executive Director of Unitaid.

Other reasons explain why this trial stands out.

First, the trial is innovative. Regulatory bodies had approved the individual medications—the first new drugs for tuberculosis in 50 years—but how to optimally combine these drugs was unknown. Rather than testing different drug regimens sequentially over a decade or longer, partners applied adaptive randomization, maximizing the number of patients who get well performing experimental regimens. This allows for a relatively small sample size (750), requires fewer resources, and may enable dramatic improvements in treatment over short periods of time.

Second, enrollment is designed to benefit all. endTB enrolled women and adolescents – groups that are often left out of clinical trials in an effort to protect them – to be sure that doctors have the data they need to best to care for them. And the consortium helped train staff at clinical sites, thus enabling more research, faster recommendations, and better treatments in the future.

Lastly, it’s significant that enrolment was completed despite massive constraints related to the COVID-19 pandemic. The COVID-19 pandemic has paused hundreds of clinical trials. Universities, hospitals, labs, and others have been forced to stall or cancel research into illnesses ranging from cancer to rare diseases. Instead, the endTB consortium adapted and continued.

“COVID-19 threatened to derail our research. We are grateful to the tireless efforts of our amazing and resilient teams who kept activities running. They made sure patient care was not compromised. This would not have been possible without teaming up with local programs and affected communities. We learnt important lessons about agility in the face of crisis.” explains Uzma Khan, endTB Project Leader and Senior Director at IRD.

This clinical trial is part of the larger endTB project that was launched to revolutionize treatment for MDR-TB patients. Approximately 2800 patients from 17 countries were enrolled in an observational study that produced strong evidence of the effectiveness of new drugs (85% culture conversion in the first 6 months of treatment) and further supports a rapid increase in access to these drugs. A second randomized controlled trial, called endTB-Q, is underway to study a 6-9 month regimen to treat the most resistant form of MDR-TB.

In addition, the endTB trial complements the TB-PRACTECAL clinical trial, also sponsored by MSF, which include another newer drug called pretomanid to provide high-quality evidence on shorter, all-oral regimens. Ultimately, both address the critical need for increased treatment options—and access—for the approximately 500,000 people who fall sick each year with MDR-TB.


Founded in 1987 by Dr. Paul Farmer, Ophelia Dahl and Dr. Jim Yong Kim, Partners In Health is a nonprofit social justice organization working to bring the benefits of modern medical science to the most vulnerable communities around the world. PIH has a documented history of implementing effective health delivery models in partnership with governments and academic institutions, including Harvard Medical School and Brigham & Women’s Hospital, helping PIH make vital contributions to curbing outbreaks and epidemics in limited-resource settings. Learn more at www.pih.org and pih.org/StopCOVID.

Doctors without Borders/Médecins Sans Frontières (MSF) provides medical assistance to people affected by conflict, epidemics, disasters, or exclusion from healthcare. Founded in 1971, MSF is today a worldwide movement of nearly 65,000 people. Our teams are made up of tens of thousands of health professionals, logistic and administrative staff allowing us to intervene in more than 70 countries. For more information: www.msf.org.

IRD Global is a global health delivery and research organization committed to improving the lives of vulnerable communities by building networks that share ideas and innovations for global impact across multiple public health concerns. IRD supports the implementation of innovative strategies to search, prevent and treat TB by drawing on prior implementation experience in private and public sector facilities and health service delivery initiatives. For more information, visit www.ird.global.

Unitaid is a global health agency engaged in finding innovative solutions to prevent, diagnose, and treat diseases more quickly, cheaply, and effectively, in low- and middle-income countries. Its work includes funding initiatives to address major diseases such as HIV/AIDS, malaria, and tuberculosis, as well as HIV co-infections and co-morbidities such as cervical cancer and hepatitis C, and cross-cutting areas, such as fever management. Unitaid is now applying its expertise to address challenges in advancing new therapies and diagnostics for the COVID-19 pandemic, serving as a key member of the Access to COVID-19 Tools (ACT) Accelerator. Unitaid is hosted by the World Health Organization.

scroll top